Be Ready for the New Oral GLP-1 Agonist Orforglipron

May 2026

You’ll get questions about orforglipron (Foundayo), the second ORAL GLP-1 receptor agonist approved for adults with overweight or obesity.

It’s another DAILY option...like oral semaglutide (Wegovy).

But orforglipron can be taken with or without food. Oral semaglutide must be taken with a max of 4 oz of water at least 30 minutes before the first food, other beverage, or oral meds of the day.

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