Pfizer is now promoting Relpax (eletriptan) for migraines. It's the seventh triptan to hit the market.
Relpax 40 mg tablets seem to be at least as effective as oral Imitrex (sumatriptan)...and might have a faster onset.
The downside is drug interactions.
Relpax is the only triptan that shouldn't be taken with potent CYP3A4 inhibitors...ketoconazole, itraconazole, nefazodone, clarithromycin, ritonavir, or nelfinavir.
These drugs boost Relpax levels and can increase the risk of adverse effects.
Other triptans have their own drug interactions. For example the Maxalt dose needs to be reduced when used with propranolol. Imitrex, Zomig, and Maxalt are contraindicated with MAOIs.
If you need help comparing the triptans, get our updated chart with doses...onset...drug interactions...etc.
Cephalalgia 2002;22:23. Neurology 2002;59:1210. Neurology 2000;54:156.